Folliculitis decalvans causes bald patches and red, crusty pustules to form on the scalp. CLINDAMYCIN (KLIN da MYE sin) treats acne. com. The cost for Clindagel topical gel 1% is around $1,881 for a supply of 75 milliliters, depending on the pharmacy you visit. Final price varies with your insurance. It is available as a foam, gel, lotion, solution. Lie on your back with knees bent or in any comfortable position. Prescriber's Guide to Texas Medicaid Outpatient Pharmacy Prior AuthorizationWisconsin Medicaid, BadgerCare Plus Standard, and SeniorCare Preferred Drug List – Quick Reference Revised 11/22/2023 Effective 11/01/2023 Page 5 of 14 Brand Before Generic DrugClindamycin phosphate topical solution USP, 1% contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per milliliter. Septic abortions are much more common after induced abortion done by untrained clinicians (or the pregnant woman herself) and without adequate surgical equipment and sterile. Doxycycline is an effective antibiotic that treats a wide range of infections. Here are some of our key products. Wisconsin Medicaid, BadgerCare Plus Standard, and SeniorCare Preferred Drug List – Quick Reference Effective 02/01/2023 Page 2 of 13 Brand Before Generic Drugcold feeling or numbness in your fingers or toes; chest pain, dry cough, wheezing, chest tightness, trouble breathing; or. Generic name: clindamycin topical Medically reviewed by Drugs. CLINICAL STUDIES In one 12-week multicenter, randomized, evaluator-blind, vehicle-controlled, parallel comparisonClindagel (Topical) Generic name: clindamycin [ klin-da-MYE-sin ] Drug class: Topical acne agents Medically reviewed by Drugs. CLINDAGEL (clindamycin phosphate) gel, 1% is indicated for topical application in the treatment of acne. FDA Approved Indications: Aczone Gel 5%, Epiduo Forte: For the topical treatment of acne vulgaris. DESCRIPTION. Clindamycin topical User Reviews & Ratings. A submandibular space infection is a bacterial infection of the floor of the mouth. Satisfaction. Post-Deductible. There was a trend in the investigator's global assessment of the results which favored Clindagel ® QD over the vehicle QD. 2-0. Carroll, PharmD Contributions by: Drs. , Aug. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. It comes as a gel, foam or cream you apply twice a day. 05% Prescribing Information. resistance has been demonstrated between clindamycin and erythromycin. Post-Deductible. Doctors may prescribe this to kill Propionibacterium acnes ( P. unusual tiredness or weakness. . Treatment is with antibiotics. 453. When including an antibiotic in your acne treatment plan, your dermatologist will prescribe it for the shortest time possible. Ini termasuk acne vulgaris yang disebabkan oleh hiperproliferasi, epidermis folikular, inflamasi, produksi keringat yang berlebihan, dan aktivitas bakteri P. How Amazon Pharmacy works. Clindac A 1% Gel is an anti-bacterial medicine. The following products are equivalent to Clindagel: Manufacturer: AMNEAL. Manufacturer Coupon. Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP]. Last updated on Nov 11, 2022. Bromhidrosis. Clindamycin phosphate 1. $38. resistance has been demonstrated between clindamycin and erythromycin. Summary of the protocol. g. Compare prices and print coupons for Clindamycin (Generic Cleocin, Cleocin T, Clindagel, and Evoclin) and other drugs at CVS, Walgreens, and other pharmacies. redness of skin. Brand names: Clindagel, Cleocin T, Clindesse, Cleocin Vaginal, Clindacin,. Prices start at $30. 23, 2021 -- Solaris Pharma Corporation announced today that the Company has received an abbreviated new drug application approval from the U. a. You may be able to lower your total cost by filling a greater quantity at one time. Perioral dermatitis describes an eruption around the mouth and nose. Establishing which treatment is the most effective will help to reduce the harms associated with late-onset infection. itching or burning skin. Clindamycin is available under different brand names and as a combination medication. The 7. changes in the color of treated skin. Pregnant patients: Vaginal cream: 1 applicatorful intravaginally once at bedtime for 7 consecutive days. Topical clindamycin may also be used for other problems as determined by your doctor. Bites are rarely fatal. Drugs. The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. A peptic ulcer is an erosion in a segment of the gastrointestinal mucosa, typically in the stomach (gastric ulcer) or the first few centimeters of the duodenum (duodenal ulcer), that penetrates through the muscularis mucosae. To help you remember to use clindamycin and benzoyl peroxide gel, apply it at around the same times every day. Generics should be considered the first line of prescribing. Generic Clindagel Availability - Drugs. ClindaMax ® Gel (Clindamycin Phosphate Gel), for topical use, contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram. Treatment. Do not take clindamycin solution and swab by mouth. oily skin. skin rash or irritation around your mouth. Common side effects of Clindacin ETZ may include: burning, itching, dryness, peeling or redness of treated skin; or. 2 out of 10 from a total of 6 reviews for the treatment of Perioral Dermatitis. Keep out of your child’s mouth, nose, and eyes (may burn). Uses; Before taking; Dosage; Warnings; Side effects; Uses for ClindagelClindamycin is usually applied twice a day, once in the morning and once in the evening, except for the foam and 1 brand of gel (Clindagel®) which are applied once a day. Look up prices and save on Clindagel and other Skin Care drugs at CVS, Walgreens, and other nearby pharmacies. Amlodipine is a prescription medication that is used with or without other medications to treat high blood pressure. Of the total drug interactions, 12 are moderate. mupirocin. 422. mupirocin. Clindamycin is an antibiotic drug used in place of penicillin. Solaris Pharma Receives Approval for First Generic Version of Clindagel. 5% strength is specifically indicated in patients 9 years of age and older. metronidazole topical may also be used for. As a guide, Clindagel topical gel 1% will cost around $1,900 for 75 milliliters. Treatment depends on stage. pharmacies start at . Compare prices and print coupons for Clindamycin (Generic Cleocin, Cleocin T, Clindagel, and Evoclin) and other drugs at CVS, Walgreens, and other pharmacies. Clindamycin or clindamycin + PNC are advocated for devastating streptococcal soft tissue infections including necrotizing fasciitis, myositis and TSS ( NEJM 334: 240, 1996. Compare prices and print coupons for Clindagel (Clindamycin) and other drugs at CVS, Walgreens, and other pharmacies. Arrhythmia in children (consider toxicity) Other side effects of digoxin include: Visual disturbance (blurred or yellow vision) Heart block (1°/2°/3°) Cardiac arrest rhythm ( asystole) Fast heart rate. 858. Tazarotene topical cream can be used to treat acne in children ages 12 years and older. A 1% clindamycin phosphate gel similar to CLINDAGELcaused a statistically significant shortening of the median time to tumor onset in a study in hairless mice in which tumors Clindamycin, Erythromycin Topical Limit, Post PA Policy UDR 04-2023. Clindamycin topical for Perioral Dermatitis User Reviews. Bienville Building 628 N. Do not take clindamycin gel and lotion by mouth. Remove the filled applicator from the tube. 9 out of 10 from a total of 229 reviews on Drugs. Solaris Pharma Receives Approval for First Generic Version of Clindagel Solaris Pharma Receives Approval for First Generic Version of Clindagel BRIDGEWATER, N. CLINDAGEL (Brand for CLINDAMYCIN PHOSPHATE) QTY 75 • 1 % • GEL DAILY • Near 77381. Clindamycin topical has an average rating of 7. S. Dosage form: topical gel. methotrexate levels, risk of serious infection, myelosuppression, nephrotoxicity, other adverse effects; may decr. MANIFESTACIONES Y MANEJO DE LA SOBREDOSIFICACIÓN O INGESTA ACCIDENTAL. Carvedilol is in a class of medications called beta-blockers. It is characterised by small red scaly papules and pustules located around the eye [1]. Clindamycin is the generic version of Clindagel. ALTRENO® (tretinoin) Lotion, 0. It belongs to a group of medications called antibiotics. Loss of appetite. Select this if your pharmacy isn’t listed above. Adapalene was approved by the FDA in 1996, but it was only available as a prescription product. 23, 2021 (GLOBE NEWSWIRE) -- Solaris Pharma Corporation (“Solaris” or the “Company”) announced today that the Company has received an abbreviated new drug. com. Accutane can cause many side effects. Serious side effects; Other side effects; Professional info; Note: This document contains side effect information about clindamycin topical. Clindamycin is an antibiotic that kills certain types of bacteria or stops them from growing. Drug monographs for clindagel or clindamycin phosphate provide an overview of the drug product, therapeutic uses, key development issues, regulatory information, and therapeutic classifications on ScriptSave WellRx. Manfaat Cindala. Food and Drug. However, it is not usually recommended for children aged less than eight. In one 12-week multicenter, randomized, evaluator-blind, vehicle-controlled, parallel comparison clinical trial in which patients used CLINDAGEL (clindamycin phosphate topical gel, 1%) once daily or the vehicle gel once daily, in the treatment of acne vulgaris of mild to moderate severity, CLINDAGEL applied once daily was more effective than the vehicle applied once daily. Clindagel Side Effects. Acne is a common condition that affects your skin. There are 12 drugs known to interact with Clindagel (clindamycin topical), along with 1 disease interaction. pimples. Hidradenitis suppurativa is currently thought to be a chronic inflammatory condition of the hair follicle and associated structures. Clindamycin phosphate gel USP, 1% contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram. Prescription only. headache. 375; noninflammatory lesions, P =. Food and Drug. Rare side effects of Clindamycin Topical include. You may report side effects to FDA at 1-800-FDA-1088. Bloody stools in a 5-day-old breastfed infant were possibly caused by concurrent maternal clindamycin 600 mg intravenously every 6 hours and gentamicin 80 mg intravenously every 8 hours. I have oily, acne-prone skin. oily skin. Isotretinoin (Accutane) is a retinoid taken as a pill to treat severe cystic acne. A 12-week study compared Clindagel, a unique water-based gel formulation of clindamycin phosphate 1%, administered once daily, and Cleocin T, a slightly different gel formulation indicated for twice-daily use, in the treatment of acne vulgaris. Fourth St. Treatment is with antibiotics (eg, clindamycin plus ceftriaxone) and. fluorouracil. It works by relaxing blood vessels so blood can flow more easily. It works by killing or preventing the growth of bacteria on your skin. Apply a thin film of CLINDAGEL once daily to the skin where acne lesions appear. Use on your skin only. Side effects of clobetasol include: thinning or softening of your skin. inhibited, decr. J. Stop using clindamycin topical and call your doctor at once if you have: severe stomach pain, diarrhea that is. AM: Cerave Acne Foaming Cleanser (4% benzoyl peroxide) Clindagel (1% clindamycin. Prescription only. An expert committee assembled by the National Rosacea Society explicitly defined and classified rosacea in April 2002. coal tar. b. the topical antimetabolite,________, inhibits cancer cells from synthesizing DNA and is used to treat basal cell and squameous cell cancers on. 80 for 1, 30gm of 1. However, consult with your doctor first before using Azithromycin during pregnancy. A difference is metronidazole is taken orally and clindamycin phosphate vaginal cream is used topically (on the skin). The Valeant Pharmacy Savings Coupon can be used up to 6 times. FAQs Progestin-Only Hormonal Birth Control: Pill and Injection. The solution, lotion, pledgets, and most brands of gel are applied twice a day. , scarring, poor self-image, depression) and results in. Cure Angular Cheilitis with Monistat and Hydrocortisone: Q. Side effects in this age group are similar to those seen in adults. Clindamycin phosphate yellow/white bottle from Dermatologistit, very watery,takes forever to dry (into a white, chalky texture), needs to be shaked, can't te. You may report side effects to FDA at 1-800-FDA-1088. g. Mediastinitis is inflammation of the mediastinum. Impetigo is a skin infection that is usually itchy and sometimes painful, and is most common in children. Get the full list here, including natural retinoids. Clindagel BID was also equivalent to Cleocin T gel BID in reducing acne lesion counts at endpoint (inflammatory lesions, P = . Box 91030 Baton Rouge, Louisiana 70821-9030 Phone: (888) 342-6207 Fax: (225) 342-9508 Name Dose Form Brand or Generic? DENAVIR CREA B DERMA-SMOOTHE/FS BODY OIL B DERMA-SMOOTHE/FS SCALP OIL B DESONATE GEL B DESONIDE. 4 out of 10 from a total of 135 reviews for the treatment of Acne. It binds to the 50S subunit of the ribosome, thus inhibiting bacterial protein synthesis. Pricing. redness, oozing or other signs of skin infection, worsening of your skin condition, severe stomach pain, and. SELIN🌶🦖 (@selguezel) bei TikTok |73. Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP]. The most common manifestation is an acute but slowly evolving localized cellulitis. Erysipelas is characterized clinically by shiny, raised, indurated, and tender plaques with distinct margins. Brand names: Clindagel, Cleocin T, Clindesse, Cleocin Vaginal, Clindacin,. coal tar. Hidradenitis suppurativa is a chronic, scarring, acnelike inflammatory process that occurs in the axillae, groin, and around the nipples and anus. com. Topical clindamycin may also be used for other problems as determined by your doctor. Acute mediastinitis usually results from esophageal perforation or occurs after median sternotomy. Amlodipine belongs to a. (clindamycin phosphate topical gel, 1%). methotrexate active metabolite levels, efficacy (decreased absorption; intestinal metab. 1 (800) 322-0808 | Toll Free Fax: 1 (855) 322-0808 . Carbuncles are clusters of furuncles connected subcutaneously, causing deeper suppuration and scarring. Topical clindamycin works best when it’s combined with other acne treatments like benzoyl peroxide. Topical clindamycin (Cleocin T, Clinda-Derm, Clindagel, Clindets, Evoclin) is an antibiotic used to stop the bacteria that causes acne. M. clindamycin topical may also be used for purposes not listed in this medication guide. CLINDAGEL (clindamycin phosphate) topical gel, 1%, a topical antibiotic, contains clindamycin phosphate, USP, at a concentration equivalent to. La información mostrada corresponde a la última IPPA (información para prescribir amplia) proporcionada por el laboratorio, por lo que podría. Its prevalence is estimated to be 0·7%. Periocular dermatitis is a localised form of periorificial dermatitis. Product description: Cleocin (Clindamycin) is an antibiotic that fights bacteria in the body. small red spots at the top of the. blisters. Side effects of metronidazole that are different from clindamycin include nausea, headache, loss of appetite, abdominal cramps, vomiting, diarrhea, dry mouth, dark colored urine, metallic taste in mouth, weight loss, dizziness. MANIFESTACIONES Y MANEJO DE LA SOBREDOSIFICACIÓN O INGESTA ACCIDENTAL. Cleocin T side effects (more detail)Solaris Pharma Corporation recently announced the company has received an abbreviated new drug application (ANDA) approval from the US FDA for the first generic version of Clindagel (clindamycin phosphate EQ 1%). It occurs when. Call your doctor for medical advice about side effects. Nasal vestibulitis is bacterial infection of the nasal vestibule, typically with Staphylococcus aureus. PatientAssistance. The average cost for 1 Bottle, 60ml of 1% each of the generic (clindamycin phosphate) is $88. It helps to decrease the number of acne lesions. It is often used to treat wounds, pyoderma, abscesses, bone and dental infections, and toxoplasmosis. People with poor dental hygiene and people who have had a tooth pulled or a jaw fracture are at higher risk. swollen hair follicles. Clindagel, like other forms of Clindamycin, has been shown to have postantibiotic effects that protect the skin. However, it is not usually recommended for children aged less than eight. September 13, 2021. Per day of therapy. Call your doctor for medical advice about side effects. Clindamycin topical side effects. Topical clindamycin is an antibiotic used to treat severe acne. Improvements may take anywhere from 2 to 12 weeks. show all brand names Clindamycin topical has. Topical clindamycin works best when it’s combined with other acne treatments like benzoyl peroxide. changes in the color of treated skin. Prescribed for Perioral Dermatitis, Bacterial Vaginosis, Acne. Accounts Receivable 800. Pseudomembranous colitis reported with nearly all antibacterial agents, including clindamycin, and may range in severity from mild to life-threatening; orally and parenterally administered clindamycin associated with severe colitis which may end fatally; diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) reported with use of orally and parenterally. Solaris Pharma Receives Approval for First Generic Version of Clindagel Solaris Pharma Receives Approval for First Generic Version of Clindagel BRIDGEWATER, N. What is Clindagel: Uses, Warnings & Interactions. Prescription only. 0280. PATIENT & CAREGIVER EDUCATION Clindamycin (Topical This information from Lexicomp explains what you need to know about this medication, including what it’sSide effects of BenzaClin Topical Gel include: dry skin, severe skin redness, burning, itching or tingly feeling, skin peeling, irritation, and. Aczone Gel is indicated for the topical treatment of acne vulgaris. Clindamycin can be used for infections (eg, skin and soft-tissue infections) in communities where community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is common; whether clindamycin is useful depends on local resistance patterns. In rare cases, bromhidrosis may become pathologic if it is particularly overpowering or if the bromhidrosis significantly interferes with the lives of the affected individuals. Clindagel is an expensive drug that is used on the skin to stop the growth of certain bacteria that cause acne. It’s prescribed to treat acne in adults and in children ages 9 years and older. 62% of reviewers reported a positive experience, while 27% reported a negative experience. May also be prescribed off label for Necrobiosis Lipoidica Diabeticorum. 995. Clindamycin is an antibiotic which works by. Clindamycin Phosphate (ab2) (Generic for Clindagel) Gel · 1% · 30-day supply. . Make sure to dry well. Brand names: Clindagel, Cleocin T, Clindesse, Cleocin Vaginal, Clindacin,. Deductible. Last updated on Dec 22, 2022. Clindamycin belongs to the family of medicines called antibiotics. This medicine works by slowing or stopping the growth of bacteria. 12K Followers, 63 Following, 67 Posts - See Instagram photos and videos from (@selinsudeguelofficial)The latest tweets from @Selinsudeguel0 Followers, 2,288 Following, 204 Posts - See Instagram photos and videos from Selin Sogutlugil (@selin_sogutlugil_official)Black Box Warnings. These hormones prevent pregnancy mainly by stopping ovulation (the release of an egg from one of the ovaries ). Clindamycin is usually applied twice a day, once in the morning and once in the evening, except for the foam and 1 brand of gel (Clindagel®) which are applied once a day. 965). If clindamycin gets into a cut or scrape, rinse it off with water. 30 days. Topical clindamycin is an antibiotic used to treat severe acne. It binds with the 50s subunit of the bacterial ribosome and inhibits the early stage of protein synthesis. Clindagel Prices -. LEYENDAS DE PROTECCIÓN. docx This document contains confidential and proprietary information of CVS Caremark and cannot be reproduced, distributed or printed without writtenWhy Legal Pot Makes This Physician Sick. It is caused by bacteria and is highly contagious. They are smaller and more superficial than subcutaneous abscesses . Metronidazole topical. If using pledgets (swabs), take pledget from the foil just before use. Clindamycin (brand names Antirobe®, Cleocin®, Clinsol®, Clintabs®) is an antibiotic used to treat a range of bacterial infections in dogs and cats. CLINDAGEL containing clindamycin phosphate equivalent to 10 mg clindamycin per gram is available in the following size: 75 mL bottle - NDC 16781-462-75. Set Price Alert. PRESENTACIÓN. Cleanse treated areas before the application of METROGEL. $35 / $65. clindamycin topical + methotrexate if oral methotrexate use, consider alternative or monitor CBC, renal fxn: combo may incr. , Aug. impetigo can be treated with. J. 866. Call your doctor for medical advice about side effects. Anthrax is caused by the gram-positive Bacillus anthracis, which are toxin-producing, encapsulated, facultative anaerobic organisms. Wash your hands before and after use. Amazon Prime members get additional benefits including FREE 2-Day Delivery and low prices on medications. Drugs in Pregnancy Dana G. 00. Clindagel® (clindamycin phosphate gel) topical gel, 1%, a topical antibiotic, contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram in a gel vehicle consisting of carbomer 941, methylparaben, polyethylene glycol 400, propylene glycol, sodium hydroxide, and purified water. It belongs to a group of medications called antibiotics. FREE – $1. BRIDGEWATER, N. In rare cases, bromhidrosis may become pathologic if it is particularly overpowering or if the bromhidrosis significantly interferes with the lives of the affected individuals. Filter by condition. 1% as an OTC product. FAQs Fertility Awareness-Based Methods of. More Ways to Save. weight loss (unusual)—these side effects may also occur up to several weeks after you stop using this medicine. I had cracked lips with sores at the corners of my mouth. Excreted into human milk: Unknown. Add to Medicine Chest. Use enough to cover the entire affected area lightly. Approval date: August 13, 2021 Strength (s): EQ 1% BASE. Clindamycin topical side effects. com . It works by reducing acne-causing bacteria. To obtain prescription medications, Prescription Hope works directly with over 180. What is Clindagel Clindamycin is an antibiotic. Pharmacology, adverse reactions, warnings and side effects. neomycin/polymixin B sulfates/ bacitracin zinc/hydrocortisone ointment 1% (Cortisporin®) neomycin/polymixin B sulfates/hydrocortisone. The typical out-of-pocket price of Clindamycin-Tretinoin without health insurance is $438. BRYHALI® (halobetasol) Lotion, 0. Clindagel may also be used for purposes not listed in this medication guide. Generic name: CLINDAMYCIN PHOSPHATE 1g in 10mL. It is usually applied twice a day, in the morning and evening. Clindagel may cause side effects. CT, ultrasonography, and MRI may help identify the cause. It is used to treat acne (a common skin condition where the pores of your skin become blocked by hair, oily substance, bacteria, and dead skin cells). 00 per month. It works by killing or preventing the growth of bacteria on your skin. Medically reviewed by Drugs. 22K Followers, 1,559 Following, 369 Posts - See Instagram photos and videos from Selin Gul 🇹🇷|🇭🇷 (@_selingul)Deje de usar clindamycin topical y llame de inmediato a su médico si usted tiene: enrojecimiento severo, picazón, o sequedad de la piel que ha recibido tratamiento;. Clindagel was safe and effective and equivalent to Cleo. Shake lotion well before use. CLINDAGEL (clindamycin phosphate) gel, 1% is indicated for topical application in the treatment of acne. itching of treated skin. Other side effects of Clindam (clindamycin) include. Clindamycin is an antibiotic which works by stopping the growth of bacteria. If any of these effects last or get worse, tell your doctor. Put a thin layer on the affected skin. Tretinoin is a retinoid. Adults: Clindagel Topical phosphate (IM or IV administration): The usual daily adult dosage of Clindagel Topical phosphate for infections of the intraabdominal area, female pelvis, and other complicated. 394; nonin- flammatory lesions, P = . Adapalene + Clindamycin is a combination of two medicines: Adapalene and Clindamycin, which treats pimples (acne). J. Keep container. También se vende bajo la marca (s): Cleocin, Ziana, Cleocin Gel, Veltin, Onexton, Evoclin, Clinda-T, Clindets, Clindasol, Clindesse,. Clindamycin is the generic version of Cleocin-T. Average total drug cost (USD) Per prescription. I would say it’s not sensitive to products. 0. Whether you decide to continue your tretinoin or switch to one of its alternatives, SingleCare coupons may help lower the cost at participating pharmacies. Diagnosis is clinical, rarely aided by culture. Clindagel prevents bacteria from growing on the skin. Doug Carroll, Elizabeth Anderson, Melissa Carter, Misty Clark, Elizabeth Flynn, LindseyCarvedilol is often used in combination with other medications. Treatment depends on stage. How to say clindagel in English? Pronunciation of clindagel with 1 audio pronunciation and more for clindagel. You could pay $7. What is a generic medication? Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication. 956) and at week 12 (inflammatory lesions, P = . It helps to decrease the number of acne lesions. Aklief is a brand-name prescription medication. Promiseb - Pay As Little As $20. 5%: For the topical treatment of acne vulgaris. Serious side effects of Clindamycin Topical include: hives, difficulty breathing, swelling of the face, lips, tongue, or throat. Orally and parenterally administered clindamycin has been associated with severe colitis, which may result in patient death.